Abstract In this paper, the antibacterial activity of triazole functionalized cyclodextrin (CD.Click) and cyclodextrin-triazole-titanium based nanocomposite (CD.COM) was evaluated. The results indicated that CD.Click and CD.COM perform a wide range of antibacterial activity against both gram positive (Staphylococcus aureus and Bacillus subtilis) and gram negative (Escherichia coli and Pseudomonas aeruginosa) bacteria. The cytotoxic effect of CD.COM was investigated in vitro on cancerous cell lines (cervical cancer, breast carcinoma and sarcoma osteogenic) and fibroblast cells by MTT assay. The cell viability evaluation confirmed that the growth of cancerous cells is inhibited in a dose and time dependent way without any significant effect on the normal fibroblast cells.

Silica-bonded S-sulfonic acid (SBSSA) was used as a recyclable and reusable catalyst for the synthesis of β-amino alcohols. Several amines were reacted with epoxides to afford regioselective β-amino alcohols in high yield under solvent-free conditions at room temperature.

Elácido S-sulfónico soportado en sílica gel (ASSSG) se utilizó como un catalizador reciclable y reutilizable para la síntesis de β-aminoalcoholes. Se hicieron reaccionar diversas aminas con epóxidos para dar de manera regioselectiva β-aminoalcoholes en rendimientos altos, a temperatura ambiente y en condiciones libres de disolventes.

An efficient protocol for the one pot regioselective synthesis of 4-bromopyrazole derivatives from 1,3-diketones, arylhydrazines and N-bromosaccharin, in the presence of silica gel supported sulfuric acid as heterogeneous catalyst, under solvent free conditions, is reported.

En este trabajo se informa de un método nuevo y eficiente para la síntesis regioselectiva y en una sola etapa de derivados del 4-bromopirazol, a partir de 1,3- dicetonas, arilhidracinas y N-bromo-sacarina empleando como catalizador ácido sulfúrico soportado en gel de sílice, en ausencia de disolvente.